Toward the bottom of this window, check the box for Reply with, and then click the Template button next to it.In the Advanced options, check the box for Only items that do not match these conditions, then click OK. Then, click the Advanced button on the right. To have the reply NOT send when the email came to a mailing list, click the Sent To… button, and find the mailing list you wish to exclude (don’t just type it in, be sure to select it from the lookup list so that it appears in the field bold with an underline).To have the reply ONLY send when you are emailed directly, check the box for Sent directly to me.Click the Rules button in the bottom left corner.You can create a custom rule, which would replace using the default Inside My Org/Outside My Org tabs for your message. This can be the same, or a different message, as the one going to MIT senders. If you also want to have replies go to people outside of MIT, select the Outside My Organization tab, check the box for auto-replies, and enter your out of office message in the area provided.Anyone with an email address will receive this reply. Add a message on the Inside My Organization tab.Click the Send automatic replies radio button, then set the date/time range you wish to have your out of office message sent.However, some users may benefit from creating a custom rule, to either only reply to certain messages, or NOT reply to certain messages. The most common way is to use the Inside Organization/Outside Organization options. Outlook offers a number of ways to customize your Automatic Reply (out of office) message. Screens may vary for other versions of Outlook.

These instructions refer to Outlook 2013.

Outlook out of office auto reply